Leoni (Elizabeth Téa Pantaleoni) stated in the October 27, 2006 issue of Life magazine that she became a Goodwill ambassador for UNICEF partially because her paternal grandmother was the president of the U.S. Fund for UNICEF for 25 years.
Leoni married her first husband, Neil Joseph Tardio, Jr., a television commercial producer, on June 8, 1991, at St. Luke's Episcopal Church in Hope, New Jersey.
Leoni married her second husband, actor David Duchovny, on May 6, 1997, after a nine-week courtship. Their first child, daughter Madelaine West Duchovny, was born on April 24, 1999, in Southern California. Their second child, a son, Kyd Miller Duchovny, was born on June 15, 2002 in Los Angeles.
On October 15, 2008, Leoni and Duchovny confirmed that they had been separated "for several months." The media attributed the separation to Duchovny's much publicized sexual addiction. The couple have since publicly reconciled and are seen frequently together as a family.
On June 29, 2011, CNN reported that Leoni and Duchovny had once again split.